Do I have a good chance at getting into NYU or Columbia?

You need AP if you want to get into NYU or Columbia. I'm going into my junior year and I'm taking AP statistics and AP Literature, as well as classes at the community college so I can earn my A.A degree by the time I graduate. I have a 4.0 and i want to major in Microbiology. And I'm still hoping I get accepted into good state schools (UF because I live in Florida and I'm shooting for Bright Futures Scholarship). If I were you, I would take much harder classes (AP) and dual enroll if your state does that if you want to even consider Columbia or NYU for Biochem.